| Autor: |
S P, Mackay, L, Comoe, B, Desoize, O, Duval, J C, Jardillier, R D, Waigh |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Anti-cancer drug design. 13(7) |
| ISSN: |
0266-9536 |
| Popis: |
Some members of a series of 12-alkyloxy benzo[c]phenanthridines are potent inhibitors of the growth of P388 tumour cells in vitro, with a strong dependence on the nature of the 12-substituent. Analogues with a quaternary nitrogen in the side chain bind strongly to DNA but are less active against the tumour cells. The multi-drug-resistant cell line Pr8/22 shows less sensitivity to the new compounds. K562 Human leukaemia cells undergo differentiation in the presence of the benzo[c]phenanthridine derivatives with a structure-activity relationship which does not correlate well with potency against the P388 cell line. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
