| Autor: |
Kelly M, Storek, Marcy R, Auerbach, Handuo, Shi, Natalie K, Garcia, Dawei, Sun, Nicholas N, Nickerson, Rajesh, Vij, Zhonghua, Lin, Nancy, Chiang, Kellen, Schneider, Aaron T, Wecksler, Elizabeth, Skippington, Gerald, Nakamura, Dhaya, Seshasayee, James T, Koerber, Jian, Payandeh, Peter A, Smith, Steven T, Rutherford |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America. 115(14) |
| ISSN: |
1091-6490 |
| Popis: |
The folding and insertion of integral β-barrel membrane proteins into the outer membrane of Gram-negative bacteria is required for viability and bacterial pathogenesis. Unfortunately, the lack of selective and potent modulators to dissect β-barrel folding in vivo has hampered our understanding of this fundamental biological process. Here, we characterize a monoclonal antibody that selectively inhibits an essential component of the |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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