[P73 gene expression in gliomas]
| Autor: | A V, Volnitskiĭ, G R, Vinogradskaia, M V, Filatov |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Voprosy onkologii. 58(4) |
| ISSN: | 0507-3758 |
| Popis: | We propose an RT-PCR primer system allowing a definite mRNA identification for different p73 (p53 homologue) isoforms identification. Using the system proposed the p73 expression was studied in 18 glioma samples (cell lines, biopsy samples, primary cultures). Most of the samples reveal no p73 expression or it is expressed simultaneously with its isoforms shown to suppress its activity. This expression pattern predisposes to cancerogenesis. |
| Databáze: | OpenAIRE |
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