| Autor: |
Bronisław, Bednarz, Tomasz, Jaxa-Chamiec, Jadwiga, Gebalska, Krystyna, Herbaczyńska-Cedro, Leszek, Ceremuzyński |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Kardiologia polska. 60(4) |
| ISSN: |
0022-9032 |
| Popis: |
In congestive heart failure (CHF), endothelial dysfunction may contribute to impairment of exercise induced vasodilatation and decreased exercise capacity. We hypothesised that administration of L-arginine, a precursor of nitric oxide (NO) and postulated antioxidant, may improve endothelium-dependent vasodilatation and exercise capacity and also exert antioxidant activity.To investigate the effect of oral supplementation with L-arginine on exercise capacity and markers of oxidative stress in patients with mild to moderate CHF.The study had a randomised double-blind cross-over design. Twenty one patients with stable NYHA II-III CHF underwent three exercise tests: initially, after oral administration of L-arginine (9 g/day for 7 days) or placebo. Blood was sampled prior to each test for plasma lipid peroxides, reduced sulphydryl groups and leukocyte oxygen free radical production.We found a higher prolongation of exercise duration time after L-arginine than after placebo (99+/-106 vs 70+/-99 s, p0.05). There were no significant differences in markers of free radical activity.In patients with chronic stable CHF, oral supplementation with L-arginine prolongs exercise duration which may be due to NO-induced peripheral vasodilatation. The antioxidant properties of L-arginine have not been confirmed in this ex vivo study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
