Major histocompatibility complex class II-dependent basophil-CD4+ T cell interactions promote TH2 cytokine-dependent immunity
| Autor: | Perrigoue, Jacqueline G., Saenz, Steven A., Siracusa, Mark C., Allenspach, Eric J., Taylor, Betsy C., Giacomin, Paul R., Nair, Meera G., Du, Yurong, Zaph, Colby, van Rooijen, Nico, Comeau, Michael R., Pearce, Edward J., Laufer, Terri M., Artis, David |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Immunoblotting Gene Expression chemical and pharmacologic phenomena Mice Inbred Strains Cell Communication Thymus Gland Article Mice Th2 Cells parasitic diseases Animals Trichuriasis Cell Proliferation Mice Knockout Reverse Transcriptase Polymerase Chain Reaction Histocompatibility Antigens Class II Immunity hemic and immune systems Flow Cytometry Schistosomiasis mansoni Basophils CD11c Antigen Mice Inbred C57BL MHC class II helminth infection Cytokines Female Interleukin-4 |
| Zdroj: | Nature immunology |
| ISSN: | 1529-2916 1529-2908 |
| Popis: | Dendritic cells can prime naive CD4+ T cells; however, here we demonstrate that dendritic cell-mediated priming was insufficient for the development of T helper type 2 cell-dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific CD4+ T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive CD4+ T cells in vivo. Collectively, our studies suggest that major histocompatibility complex class II-dependent interactions between basophils and CD4+ T cells promote T helper type 2 cytokine responses and immunity to helminth infection. |
| Databáze: | OpenAIRE |
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