| Autor: |
Trenton D, Colburn, Ramona E, Weber, Kiana M, Schulze, K Sue, Hageman, Andrew G, Horn, Brad J, Behnke, David C, Poole, Timothy I, Musch |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
J Physiol |
| ISSN: |
1469-7793 |
| Popis: |
Vascular ATP-sensitive K(+) (K(ATP)) channels support skeletal muscle blood flow (Q̇m), interstitial O(2) delivery (Q̇O(2))-utilization (V̇O(2)) matching (i.e., interstitial-myocyte O(2) flux driving pressure; PO(2)is) and exercise tolerance. Potential sex differences in skeletal muscle vascular K(ATP) channel function remain largely unexplored. We hypothesized that local skeletal muscle K(ATP) channel inhibition via glibenclamide superfusion (5 mg kg(−1) GLI; sulfonylurea diabetes medication) in anesthetized female Sprague-Dawley rats, compared to males, would demonstrate greater reductions in contracting (1 Hz, 7V, 180 s) fast-twitch oxidative mixed gastrocnemius (97% type IIA+IID/X+IIB) Q̇m (15 µm microspheres) and PO(2)is (phosphorescence quenching), resulting from more compromised convective (Q̇O(2)) and diffusive (DO(2)) O(2) conductances. Further that these GLI-induced reductions in ovary-intact females measured during proestrus would be diminished following ovariectomy (F+OVX). GLI similarly impaired mixed gastrocnemius V̇O(2) in both males (↓28%) and females (↓33%, both P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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