Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling★

Autor:	Ma, Yinghuan, Bao, Yongxin, Li, Chenghao, Jiao, Fubin, Xin, Hongjie, Yuan, Zhengwei
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	congenital hereditary and neonatal diseases and abnormalities caspase-3 neural tube defects mitogen-activated protein kinase myeloid tissues regeneration retinoic acid apoptotic kinase neural regeneration Article c-Jun N-terminal kinase nervous system diseases neural development
Zdroj:	Neural Regeneration Research
ISSN:	1876-7958 1673-5374
Popis:	Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofluorescence assay and western blot analysis showed that the number of caspase-3 positive cells in myeloid tissues for spina bifida manifesta was increased. There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. The c-Jun N-terminal kinase phosphorylation level was positively correlated with caspase-3 expression in myeloid tissues for spina bifida manifesta. Experimental findings indicate that abnormal apoptosis is involved in retinoic acid-induced dominant spina bifida formation in fetal rats, and may be associated with the c-Jun N-terminal kinase signal transduction pathway.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::06b64cd004bde5127a934ff7f8623736 http://europepmc.org/articles/PMC4200703 Zobrazit plný text záznamu