| Autor: |
Takashi, Tawara-Iida, Joichi, Usui, Itaru, Ebihara, Takashi, Ishizu, Masaki, Kobayashi, Yoshitaka, Maeda, Hiroaki, Kobayashi, Tokuro, Kobayashi, Atsushi, Ueda, Makoto, Tsuchida, Shinichiro, Sakai, Kunihiro, Yamagata, Toshihiro, Fujii |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
BMC nephrology. 23(1) |
| ISSN: |
1471-2369 |
| Popis: |
Patients with end-stage kidney disease (ESKD) face higher risks of life-threatening events including cardiovascular disease. Various risk factors are identified as agents influencing the life prognosis of ESKD patients. Herein, we evaluated the risk factors related to the outcomes of Japanese patients with dialysis induction. We present the study protocol, the patients' baseline characteristics, and their outcomes.The Ibaraki Dialysis Initiation Cohort (iDIC) Study is a prospective multi-center cohort study in collaboration with 60 tertiary-care facilities in Ibaraki Prefecture, Japan. We collected baseline data from clinical records and analyzed blood and urine samples of these facilities' patients with diabetic nephropathy, hypertensive nephrosclerosis, and chronic glomerulonephritis (CGN). The study's primary outcome was the survival rate at 24 months after dialysis induction. We performed a Kaplan-Meier analysis for cumulative survival and a Cox proportional hazards analysis for all-cause mortality and hospitalization.We analyzed 636 patients' cases (424 males, 212 females, age 67.4 ± 13.1 yrs. [mean ± SD]). We compared the patients' baseline data with those of similar cohort studies. As the primary kidney disease, 327 cases (51.4%) were diagnosed as diabetic nephropathy, 101 (15.9%) as hypertensive nephrosclerosis, and 114 (17.9%) as CGN. The mean serum creatinine value was 9.1 ± 2.9 mg/dL. The mean estimated glomerular filtration rate was 5.6 ± 1.8 mL/min/1.73mRegarding the clinical characteristics of these newly induced dialysis patients, the same trend as in other cohort studies was observed. Another study is underway to explore prognostic factors based on the iDIC Study's findings. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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