Onset of Analgesia and Efficacy of Ibuprofen Sodium in Postsurgical Dental Pain
| Autor: | Brain, Patrick, Leyva, Rina, Doyle, Geraldine, Kellstein, David |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pain Postoperative Time Factors Adolescent analgesia Ibuprofen Original Articles Analgesics Non-Narcotic dental pain Young Adult Treatment Outcome Double-Blind Method fast-absorbed ibuprofen ibuprofen sodium dihydrate Tooth Extraction Reaction Time Humans Female over-the-counter Pain Measurement |
| Zdroj: | The Clinical Journal of Pain |
| ISSN: | 1536-5409 0749-8047 |
| Popis: | Objectives: A novel, immediate-release tablet formulation of ibuprofen (IBU) sodium dihydrate, Advil Film Coated Tablets (IBUNa), has been developed that is absorbed faster than standard IBU tablets. The objective of the current study was to compare the efficacy and onset of analgesia of this new formulation with standard IBU tablets after a single dose. Materials and Methods: Patients (N=316) with at least moderate baseline postsurgical dental pain were randomized to 400 mg IBUNa, Advil (IBUAdv), Motrin (IBUMot), or placebo. Primary endpoints were time-weighted sum of pain relief (PR) and pain intensity differences over 8 hours (SPRID 0-8) and time to onset of meaningful pain relief (TMPR) measured by the double-stopwatch method. Results: SPRID 0-8 was significantly greater for IBUNa and the other active treatments versus placebo (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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