[Increased INR from concomitant use of acenocoumarol and capecitabine]

Autor:	Ben, Tomlow, Marsha L, Voll, Carolien H, Smorenburg
Jazyk:	Dutch; Flemish
Rok vydání:	2012
Předmět:	Aged 80 and over Antimetabolites Antineoplastic Rectal Neoplasms Acenocoumarol Anticoagulants Heparin Low-Molecular-Weight Deoxycytidine Atrial Fibrillation Humans Drug Interactions Female Fluorouracil International Normalized Ratio Erythrocyte Transfusion Gastrointestinal Hemorrhage Capecitabine
Zdroj:	Nederlands tijdschrift voor geneeskunde. 156(26)
ISSN:	1876-8784
Popis:	A drug interaction between capecitabine and coumarin may result in an increased INR and bleeding complications.We describe an 80-year-old woman who presented with rectal bleeding and an increased INR due to the concomitant use of acenocoumarol and capecitabine for atrial fibrillation and metastatic cecal cancer, respectively.In patients with a compelling indication for treatment with capecitabine and anticoagulant therapy, conversion to low-molecular weight heparin should be considered.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::06896dbbf8627722f2a2121833331403 https://pubmed.ncbi.nlm.nih.gov/22759711 Zobrazit plný text záznamu