Renal Calcium Oxalate Deposits Induce a Pro-Atherosclerotic and Pro-Osteoporotic Response in Mice

Autor: Kirsten, Kusumi, Evan, Barr-Beare, Vijay, Saxena, Fayez, Safedi, Andrew, Schwaderer
Rok vydání: 2017
Předmět:
Zdroj: Journal of cellular biochemistry. 118(9)
ISSN: 1097-4644
Popis: Urinary stone disease (USD) is increasing in adult and pediatric populations. Adult and pediatric studies have demonstrated decreased bone mineral density and increased fracture rates. USD has also been independently linked to increased rates of myocardial infarction and cerebral vascular accidents. Although USD is a multisystem disorder involving the kidneys, bone, and vasculature, the molecular mechanisms linking these three organs remain unknown. Calcium oxalate nephropathy was induced in C57BL/6J mice with intra-peritoneal (ip) injection of sodium glyoxolate. Half of each kidney underwent Pizzalato staining and half was snap frozen for RNA extraction. RT
Databáze: OpenAIRE