Epstein-Barr virus-associated primary central nervous system lymphoma in a child with the acquired immunodeficiency syndrome. A case report and review of the literature
| Autor: | M M, Rodriguez, P I, Delgado, C K, Petito |
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| Rok vydání: | 1998 |
| Předmět: |
Central Nervous System
Male Acquired Immunodeficiency Syndrome Herpesvirus 4 Human Lymphoma B-Cell Brain Herpesviridae Infections Immunophenotyping Klebsiella Infections Central Nervous System Neoplasms Diagnosis Differential Tumor Virus Infections Child Preschool Klebsiella Pseudomonas Pneumonia Bacterial Humans RNA Viral Pseudomonas Infections Lymphocytes Tomography X-Ray Computed In Situ Hybridization |
| Zdroj: | Archives of pathologylaboratory medicine. 121(12) |
| ISSN: | 0003-9985 |
| Popis: | A 34-month-old black boy who had contracted acquired immunodeficiency syndrome from his mother presented with fever, vomiting, and cough. He was cachectic, hypertonic, and developmentally delayed. A brain computed tomography scan revealed masses in the left frontal horn, subependymal, and periventricular regions; secondary edema; and hydrocephalus. The differential diagnosis was cerebral lymphoma versus toxoplasmosis. The patient had disseminated Mycobacterium avium-intracellulare infection, lymphoid interstitial pneumonitis, as well as Pseudomonas and Klebsiella pneumonia. He died of respiratory insufficiency 53 days after admission. The autopsy confirmed a primary cerebral B-cell lymphoma, large cell type, which was positive for Epstein-Barr virus, latent phase, by in situ hybridization. Primary central nervous system lymphomas are rare in children, in contrast to adults. To our knowledge, only five well-documented cases of primary cerebral lymphomas in infants and children with acquired immunodeficiency syndrome have been reported previously. The current study shows that these childhood lymphomas are associated with and presumably caused by Epstein-Barr virus and thus have a pathogenesis similar to that of primary central nervous system lymphomas in adults. |
| Databáze: | OpenAIRE |
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