[Delirium on re-starting clozapine after a short break in treatment]

Autor: J A W, Benckhuijsen, I P M, Keet
Jazyk: Dutch; Flemish
Rok vydání: 2007
Předmět:
Zdroj: Tijdschrift voor psychiatrie. 49(9)
ISSN: 0303-7339
Popis: Extra care must be taken in treating patients with clozapine because of the serious side-effects. A 44-year-old man with schizophrenia developed delirium on two occasions immediately after restarting clozapine at the dosage he had previously tolerated well; the clozapine-free periods had lasted 2 and 10 days respectively. Because of this 're-challenge' it seems very likely that there is a causal relation between the direct resumption of treatment with clozapine and delirium. Even if clozapine treatment is interrupted for only a short time it is important that the 'new' course begins with a low dosage and is increased very cautiously until it reaches the former, tolerated level.
Databáze: OpenAIRE