| Autor: |
A, Tostmann, J P M, Wielders, G S, Kibiki, H, Verhoef, M J, Boeree, A J A M, van der Ven |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 14(9) |
| ISSN: |
1815-7920 |
| Popis: |
Vitamin D deficiency is associated with susceptibility to active tuberculosis (TB) in many settings. In vitro studies and studies on human volunteers showed that two of the first-line anti-tuberculosis drugs, isoniazid and rifampicin, reduce 25-hydroxy vitamin D (25[OH]D) concentrations.To study changes in vitamin D status during treatment of Tanzanian hospitalised patients with pulmonary TB (PTB).We compared serum 25[OH]D concentrations in 81 Tanzanian PTB patients before and after 2 months of treatment.Median serum 25[OH]D concentrations increased from 91 nmol/l at baseline to 101 nmol/l after 2 months of TB treatment (median increase 6.0 nmol/l, IQR -0.7-25.0, P = 0.001). Median serum parathyroid hormone concentrations increased from 1.6 to 2.0 pmol/l (median increase 0.46, IQR -0.2-1.1, P0.001).25[OH]D serum concentrations increased during the first 2 months of TB treatment in 81 PTB patients in northern Tanzania. Improved dietary intake and increased sunlight exposure may have contributed to the increased 25[OH]D concentrations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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