| Autor: |
A, Bhattacharya, R, Shukla, K N, Dietrich, J, Miller, A, Bagchee, R L, Bornschein, C, Cox, T, Mitchell |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Neurotoxicology. 14(2-3) |
| ISSN: |
0161-813X |
| Popis: |
Measurement of postural equilibrium has been employed as an indirect indicator of functional status of the nervous systems of 109 children (mean age: 5.8 +/- 0.78 years) from the Cincinnati Lead Program Project. The geometric mean blood lead for the first five years of life (PbB05) was 11.9 +/- 1.5 micrograms/dL. Postural sway associated with upright balance was noninvasively quantitated with a microprocessor-based force platform and four tasks performed for 30 sec each by the subjects. A covariate-adjusted multiple regression analysis showed statistically significant associations between PbB05 and the postural sway for the task requiring primarily vestibular and/or proprioceptive systems input, implying potential functional impairment. These findings raised several new issues which are addressed here: (1) A dynamic task has been developed to further test the effect of perturbing those afferents' functional capabilities. (2) A method has been developed to quantitate the stability boundary of each subject to better characterize the limits of functionally-safe postural sway. (3) There is a need to perform the postural sway in a shorter duration than 30 sec so that children younger than five years of age can be tested for early identification of Pb-induced functional impairment of postural equilibrium. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
