| Autor: |
Shun-Chin, Yang, Yi-Hsuan, Wang, Yung-Fong, Tsai, Ya-Wen, Chang, Tian-Shung, Wu, Chiu-Ming, Ho, Tsong-Long, Hwang |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(5) |
| ISSN: |
1530-6860 |
| Popis: |
Human neutrophils have a vital role in host defense and inflammatory responses in innate immune systems. Growing evidence shows that the overproduction of reactive oxygen species and granular proteolytic enzymes from activated neutrophils is linked to the pathogenesis of acute inflammatory diseases. However, adequate therapeutic targets are still lacking to regulate neutrophil functions. Herein, we report that MVBR-28, synthesized from the Mannich bases of heterocyclic chalcone, has anti-neutrophilic inflammatory effects through regulation of intracellular pH. MVBR-28 modulates neutrophil functions by attenuating respiratory burst, degranulation, and migration. Conversely, MVBR-28 has no antioxidant effects and fails to alter elastase activity in cell-free systems. The anti-inflammatory effects of MVBR-28 are not seen through cAMP pathways. Significantly, MVBR-28 potently inhibits extracellular Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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