Behavioural responses of gamma-MSH peptides administered into the rat ventral tegmental area

Autor:	V, Klusa, S, Svirskis, B, Opmane, R, Muceniece, J E, Wikberg
Rok vydání:	1999
Předmět:	Male Catalepsy gamma-MSH Behavior Animal Microinjections Ventral Tegmental Area Animals Motor Activity Rats Wistar Grooming Rats
Zdroj:	Acta physiologica Scandinavica. 167(2)
ISSN:	0001-6772
Popis:	The behavioural effects induced by alpha-, gamma1- and gamma2-MSH peptides (0.3 and 3 nmole per rat) injected into the left ventral tegmental area (VTA) of rats were compared. alpha- and gamma1-MSH caused grooming of comparable magnitude, and also additional vertical activity (rearing). By contrast gamma2-MSH caused a moderate but stable catalepsy, and practically no grooming. Moreover, intra-VTA pre-treatment with gamma2-MSH, 15 min prior to intra-VTA gamma1-MSH, markedly attenuated both the gamma1-induced grooming and vertical activities. The differences in the behavioural response of the MSH peptides indicate that they act differentially on MC receptors in the VTA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::05fbea33bc08177375495b258b4cc4c2 https://pubmed.ncbi.nlm.nih.gov/10571544 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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