[Sodium oxybutyrate normalizes the central nervous system functions in the progeny of rats subjected to hypobaric hypoxia during pregnancy]

Autor:	S S, Trofimov, R U, Ostrovskaia, N M, Smol'nikova, E V, Kravchenko, O A, Kutepova, N A, Bondarenko, L N, Nerobkova, E P, Nemova, T A, Voronina
Rok vydání:	1993
Předmět:	Central Nervous System Male Atmosphere Exposure Chambers Time Factors Conditioning Classical Drug Evaluation Preclinical Fetal Hypoxia Rats Escape Reaction Memory Pregnancy Prenatal Exposure Delayed Effects Reaction Time Animals Female Sodium Oxybate
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 56(6)
ISSN:	0869-2092
Popis:	Two-hour hypobaric hypoxia of rats on day 15 of their pregnancy led to a reduction in weight gain of pups within 20 days after birth, disturbed memory in active and passive paradigms, changed adaptive behavior in the extrapolatory water avoidance test, and impaired sleep in adult animals. Postnatal treatment with sodium hydroxybutyrate given in a dose of 50 mg/kg/day on days 8 to 20 of life normalized mnestic functions of the brain, the process of falling asleep, and physical development which had been impaired by intrauterine hypoxia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::05f646766c6da3555db3f4c4f9896afb https://pubmed.ncbi.nlm.nih.gov/8111305 Zobrazit plný text záznamu