The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues

Autor:	Philip R, Taylor, Matthew C, Pickering, Marie H, Kosco-Vilbois, Mark J, Walport, Marina, Botto, Siamon, Gordon, Luisa, Martinez-Pomares
Rok vydání:	2002
Předmět:	Antibodies Monoclonal Complement C4 Antigen-Antibody Complex Complement System Proteins Kidney Immunohistochemistry Mice Inbred C57BL Mice Glomerulonephritis Animals Epitopes B-Lymphocyte Complement Activation Biomarkers Dendritic Cells Follicular
Zdroj:	European journal of immunology. 32(7)
ISSN:	0014-2980
Popis:	We have identified the murine follicular dendritic cell (FDC) marker, FDC-M2, recognized by monoclonal antibody mAb209, as complement component C4. Consistent with this, FDC-M2 was detectable at sites of immune complex-mediated inflammatory disease. Analysis of FDC-M2 distribution in complement-deficient mice highlighted the differences in immune complex clearance between these mice, andshowed that a population of uncharacterized FDC-M2+ reticular and perivascular cells in the spleen, distinct from FDC, are also involved in immune complex capture and possibly retention. These results demonstrate that mAb209, in addition to its role as an FDC marker, is a valuable reagent for the analysis of complement deposition in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::05b4dae7ee5b552c74a0d1d265ce257b https://pubmed.ncbi.nlm.nih.gov/12115608 Zobrazit plný text záznamu Plný text