| Autor: |
I V, Fel'dblium, N N, Vorob'eva, A M, Nikolaeva, V N, Borisova, V A, Mel'nikov, M V, Budanov, I A, Iakovleva, A V, Kaz'ianin, E V, Pushkareva, V N, Griaznov, D V, Griaznova, N V, Shalunova, O V, Perelygina, N A, Ozeretskovskiĭ, T A, Bektimirov |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Zhurnal mikrobiologii, epidemiologii i immunobiologii. (6) |
| ISSN: |
0372-9311 |
| Popis: |
Bubo-M, the first Russian combined vaccine, was found to have low reactogenicity. The difference between the number of postvaccinal reactions in the group of children immunized with Bubo-M (25.9%) and those in the group of children who had been simultaneously injected into different sites of the body with ADS-M toxoid (adsorbed DT toxoid with reduced antigen content) and hepatitis B vaccine (26.7%) was not statistically significant. Following immunization a considerable increase in the level of diphtheria and tetanus antibodies (p0.005) was observed in all children (100%), the level of HBs antibodies in the group of children immunized with Bubo-M (the geometric mean titer: 13,721 IU/l) essentially exceeding that observed in the control group injected with ADS-M toxoid and hepatitis B vaccine (the geometric mean of the titer: 2,441 IU/l). Bubo-M was duly registered and allowed for industrial production and medical use. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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