Multimodality Imaging of the Effects of a Novel Dentifrice on Oral Biofilm

Autor: Ajdaharian, Janet, Dadkhah, Mohammad, Sabokpey, Sara, Biren-Fetz, John, Chung, Na Eun, Wink, Cherie, Wilder-Smith, Petra
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Popis: Oral biofilm formation and progression on the surface of the tooth can lead to advanced oral disease such as gingivitis. The purpose of this randomized, controlled, double-blinded study was to evaluate the effects of a novel dental gel on oral plaque biofilm using multimodal imaging techniques.Twenty-five subjects with moderate gingival inflammation (Löe and Silness Gingival Index ≥2) and pocket depths4 were randomly assigned to brush twice daily for 21 days with the test or the control dental gel. In vivo multimodality in situ imaging was performed over a 3-week period using in vivo Optical Coherence Tomography (OCT) and Non-Linear Optical microscopy (NLOM). Plaque levels, gingival inflammation and gingival bleeding were also charted on days 0, 7, 14, and 21 using standard clinical indices.After 3 weeks, OCT and NLOM images showed a macroscopic break-up of the plaque layer and smaller, fragmented residual deposits in the test group with no apparent changes in the pellicle. Biofilm was also reduced in the control group, but to a lesser degree with regard to thickness, continuity and surface area. Paralleling these imaging results, clinical indices were significantly improved in both groups (P 0.05) and significantly lower in the test group (P 0.05).Both dental gels reduced oral biofilm with the test gel showing greater efficacy (P 0.05) as determined by clinical and imaging parameters.
Databáze: OpenAIRE