| Autor: |
S I, Gavrilova, I V, Kolykhalov, G I, Korovaĭtseva, G A, Zharikov, Ia B, Kalyn, N D, Selezneva |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 105(4) |
| ISSN: |
1997-7298 |
| Popis: |
Correlation association between an ApoE4 genotype in patients with mild-moderate Alzheimer's disease and efficacy of neurotrophic (cerebrolysin) and cholinergic (exelon) therapy was studied in the groups of patients formed using case-control method. A 4-month treatment has shown that both types of therapy had a significant clinical effect, however clinical effect proved to be more higher and stable in patients treated with cerebrolysin. A number of responders in the cerebrolysin group was 1.7-fold higher comparing to that in the exelon group. Patients with the ApoE4(+) genotype did not differ in response to either drug but in those with genotype ApoE4(-) the number of responders was 3-fold higher in the group treated with cerebrolysin compared to the group given exelon. A follow-up estimation of cognitive impairment in ApoE4(-) patients revealed that long-term clinical effect of cerebrolysin treatment was 6.5 times higher than that of exelon. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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