Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection

Autor:	Matthias, Kästle, Camilla, Merten, Roland, Hartig, Carlos, Plaza-Sirvent, Ingo, Schmitz, Ursula, Bommhardt, Burkhart, Schraven, Luca, Simeoni
Rok vydání:	2022
Předmět:	src Homology Domains Mice src-Family Kinases Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Phospholipase C gamma Receptors Antigen T-Cell Animals Thymus Gland Phosphorylation Signal Transduction
Zdroj:	International journal of molecular sciences. 23(13)
ISSN:	1422-0067
Popis:	Signaling via the TCR, which is initiated by the Src-family tyrosine kinase Lck, is crucial for the determination of cell fates in the thymus. Because of its pivotal role, ablation of Lck results in a profound block of T-cell development. Here, we show that, in addition to its well-known function in the initiation of TCR signaling, Lck also acts at a more downstream level. This novel function of Lck is determined by the tyrosine residue (Y192) located in its SH2 domain. Thymocytes from knock-in mice expressing a phosphomimetic Y192E mutant of Lck initiate TCR signaling upon CD3 cross-linking up to the level of PLC-γ1 phosphorylation. However, the activation of downstream pathways including Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::056d622191a40ff4097c53a3cf1f8eb3 https://pubmed.ncbi.nlm.nih.gov/35806279 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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