Challenging Issues in Clinical Trial Design: Part 4 of a 4-Part Series on Statistics for Clinical Trials

Autor:	Stuart J, Pocock, Tim C, Clayton, Gregg W, Stone
Rok vydání:	2015
Předmět:	Clinical Trials as Topic Data Interpretation Statistical Cardiology Humans Guidelines as Topic Clinical Trials Data Monitoring Committees
Zdroj:	Journal of the American College of Cardiology. 66(25)
ISSN:	1558-3597
Popis:	As a sequel to last week's paper on the fundamentals of clinical trial design, this paper tackles related controversial issues: noninferiority trials, the value of factorial designs, the importance and challenges of strategy trials, Data Monitoring Committees (including when to stop a trial early), and the role of adaptive designs. All topics are illustrated by relevant examples from cardiology trials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::053f84efb42208f125d37f5571fcf3a8 https://pubmed.ncbi.nlm.nih.gov/26718676 Zobrazit plný text záznamu