Glucocorticoids, antenatal corticosteroid therapy and fetal heart maturation
| Autor: | Agnew, Emma J, Ivy, Jessica R, Stock, Sarah J, Chapman, Karen E |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
antenatal corticosteroid
HPA axis steroid preterm birth Review heart programming lung Fetal Development fetal origins Fetal Heart Adrenal Cortex Hormones 11-beta-Hydroxysteroid Dehydrogenase Type 1 Animals Humans Premature Birth glucocorticoid 11β-HSD Glucocorticoids hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Molecular Endocrinology |
| ISSN: | 1479-6813 0952-5041 |
| Popis: | Glucocorticoids are essential in mammals to mature fetal organs and tissues in order to survive after birth. Hence, antenatal glucocorticoid treatment (termed antenatal corticosteroid therapy) can be life-saving in preterm babies and is commonly used in women at risk of preterm birth. While the effects of glucocorticoids on lung maturation have been well described, the effects on the fetal heart remain less clear. Experiments in mice have shown that endogenous glucocorticoid action is required to mature the fetal heart. However, whether the potent synthetic glucocorticoids used in antenatal corticosteroid therapy have similar maturational effects on the fetal heart is less clear. Moreover, antenatal corticosteroid therapy may increase the risk of cardiovascular disease in adulthood. Here, we present a narrative review of the evidence relating to the effects of antenatal glucocorticoid action on the fetal heart and discuss the implications for antenatal corticosteroid therapy. |
| Databáze: | OpenAIRE |
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