| Autor: |
D O, Levitskiĭ, E V, Grishin, T V, Biriukova, A V, Lebedev, L N, Nikolaeva |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR. 4(2) |
| ISSN: |
0201-7369 |
| Popis: |
The data are presented on fractionation of cardiac and skeletal muscle Ca2+-ATPase fragments obtained by trypsin and cyanobromide hydrolysis. Amino acid composition of Ca2+-ATPases isolated from the heart and skeletal muscles and of enzyme fragments is determined. The ionophoric properties of the intact enzyme and its fragments are studied. The low-molecular weight enzyme fragment decreases velocity and the level of Ca2+-accumulation by the vesicles of sarcoplasmic reticulum. It is suggested that an "ionphoric" fragment of muscle ATPase is able to form transmembrane Ca2+-selective channel in model lipid membranes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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