| Autor: |
Z, Pelin, C, Guilleminault, N, Risch, F C, Grumet, E, Mignot |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Tissue antigens. 51(1) |
| ISSN: |
0001-2815 |
| Popis: |
Narcolepsy is a neurological disorder known to be tightly associated with HLA-DQA1*0102 and DQB1*0602. In this study, we have examined if homozygosity for DQB1*0602 increases disease susceptibility and/or severity. Patients diagnosed at Stanford University (n=160) or enrolled in a multicenter clinical trial (n=509) were included in this analysis. In both African-Americans and Caucasian-Americans with or without cataplexy, a significantly higher than expected number of subjects were DQB1*0602 homozygotes. Relative risks were 2-4 times higher in DQB1*0602 homozygotes vs heterozygotes across all patient groups. In contrast, symptom severity did not differ between DQB1*0602 homozygous and heterozygous subjects. These results indicate that HLA-DQB1*0602 homozygosity increases susceptibility to narcolepsy but does not appear to influence disease severity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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