[The effect of dithiothreitol on the thrombin coagulating activity]

Autor: A A, Sereĭskaia, N V, Kostiuchenko, T V, Osadchuk, S B, Serebrianyĭ
Rok vydání: 1983
Předmět:
Zdroj: Ukrainskii biokhimicheskii zhurnal (1. 55(3)
ISSN: 0201-8470
Popis: Partial dithiothreitol-reduction of the disulphide thrombin bonds when denaturating agents are absent lowers significantly enzymic activity of thrombin relative to fibrinogen coagulation. This permits supposing that at least one of the disulphide bridges in a thrombin molecule is necessary for stabilization of the space structure important for a specific hydrolysis of fibrinogen.
Databáze: OpenAIRE