3-Hydrazinopyridazine derivatives as inhibitors of pyridoxal-phosphate dependent enzymes

Autor:	F, Buffoni, C, Carpi, G, Banchelli Soldaini, L, Raimondi
Rok vydání:	1980
Předmět:	Male Blood Pressure In Vitro Techniques Mitochondria Rats Pyridazines Hydrazines Pyridoxal Phosphate Animals Aromatic Amino Acid Decarboxylase Inhibitors Female Amine Oxidase (Copper-Containing) Aspartate Aminotransferases Enzyme Inhibitors
Zdroj:	Il Farmaco; edizione scientifica. 35(10)
ISSN:	0430-0920
Popis:	A series 3-hydrazinopyridazine derivatives with anti-hypertensive properties was studied as inhibitors of pyridoxal-phosphate dependent enzymes. All the compounds with a free hydrazino group were found to be strong inhibitors in vitro. In vivo inactive compounds became active at doses which exert a hypotensive action. The significance of this inhibition is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::04b150c5f7093306606dc381de633ff7 https://pubmed.ncbi.nlm.nih.gov/6778712 Zobrazit plný text záznamu