[Investigation into the vestibular protective properties of melatoninergic agents]
| Autor: | V V, Iasnetsov, V G, Motin, S K, Karsanova, Vic V, Iasnetsov, Iu V, Ivanov, N A, Chel'naia |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Neurons Medulla Oblongata Patch-Clamp Techniques Receptor Melatonin MT2 Receptor Melatonin MT1 Central Nervous System Depressants Excitatory Postsynaptic Potentials Bicuculline Tryptamines Rats Animals Newborn Acetamides Animals Outbred Strains Animals GABA-A Receptor Antagonists Vestibule Labyrinth Melatonin |
| Zdroj: | Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine. 48(2) |
| ISSN: | 0233-528X |
| Popis: | Experiments with rats showed that melatonin (2.5 mg/kg) produces a distinct vestibular protective effect excelling promethazine (50 mg/kg) as a reference agent, and also antidepressant agomelatine (5 mg/kg) as another melatoninergic agent. Lusindol, a blocker of MT1/MT2-receptors (2.5 mg/kg), and bicuculline (1.5 mg/kg), a specific GABA-receptors antagonist, weakened the melatonin effect significantly. The results testify mediation of the melatonin action by these receptors. Whole-cell patch clamp in an experiment with convoluted oblongata sections from white nonlinear infant male rats (14-d old) disclosed that melatonin (2 mM) inhibited drastically (29 +/- 3%) the excitatory postsynaptic current caused by depolarization step in neurons of the medial vestibular nucleus. Lusindol (0.1 mM) inhibited the effect of melatonin (2 mM) significantly (71 +/- 6%) which suggests involvement of melatonin MT1/MT2-receptors. |
| Databáze: | OpenAIRE |
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