Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation
| Autor: | Lassad, Oussaief, Aurélie, Hippocrate, Vanessa, Ramirez, Aurore, Rampanou, Wei, Zhang, David, Meyers, Philip, Cole, Ridha, Khelifa, Irène, Joab |
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| Rok vydání: | 2009 |
| Předmět: |
Gene Expression Regulation
Viral Mitogen-Activated Protein Kinase 1 Herpesvirus 4 Human Mitogen-Activated Protein Kinase 3 MAP Kinase Signaling System Mechanisms of Signal Transduction Acetylation CREB-Binding Protein Transforming Growth Factor beta1 Phosphatidylinositol 3-Kinases Viral Proteins Cell Line Tumor Trans-Activators Humans Virus Activation Smad3 Protein Proto-Oncogene Proteins c-akt |
| Zdroj: | The Journal of biological chemistry. 284(36) |
| ISSN: | 0021-9258 |
| Popis: | Epstein-Barr virus, a ubiquitous human herpesvirus, is associated with the development of carcinomas and lymphomas. We previously showed that transforming growth factor beta1 (TGF-beta1) mediated the virus to enter the lytic cycle, which is triggered by expression of Z Epstein-Barr virus replication activator (ZEBRA), through the ERK 1/2 MAPK signaling pathway. We report here that Akt, activated downstream from ERK 1/2, was required for TGF-beta1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-beta1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein and then to regulate TGF-beta1-induced ZEBRA expression. |
| Databáze: | OpenAIRE |
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