| Autor: |
A, Estrela-Lima, M S S, Araújo, R P, Soares, L G R, Ribeiro, K A, Damasceno, A T, Costa, A, Teixeira-Carvalho, O A, Martins-Filho, G D, Cassali |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Veterinary and comparative oncology. 14(1) |
| ISSN: |
1476-5829 |
| Popis: |
The immunological biomarkers profiles were evaluated using Luminex as putative measures to monitor canine mammary carcinomas (MCs). Forty female dogs were categorized into benign mixed tumour (MC-BMT = 28) and mammary carcinoma (MC=12). The ascendant biomarker signatures were used to compare the groups. For example, a higher frequency of MC-BMT animals producing IL-6, CXCL-8 and CXCL-10 was observed, whereas for the MC group IL-2 and CXCL-8 were detected. MC-BMT animals without metastasis had an increase in the levels of IL-2, CXCL-8, CXCL-10, IL-6, TNF-α, IL-15 and a decrease in IL-10 and CXCL-8. MC-BMT animals with metastasis showed only an increase in CXCL-10 and a decrease in IL-18. After comparing the ascendant signatures following the presence of metastasis in both groups, a higher frequency of dogs exhibiting IL-10 production was observed. Pearson correlation (P = 0.0273) and receiver operating characteristic (ROC) curve analysis revealed that this pattern was associated with worse outcome and lower survival rates in MC animals. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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