| Autor: |
T, Wang, K, Nakajima, E T, Leary, G R, Warnick, J S, Cohn, P N, Hopkins, L L, Wu, D D, Cilla, J, Zhong, R J, Havel |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Clinical chemistry. 45(11) |
| ISSN: |
0009-9147 |
| Popis: |
Familial type III hyperlipoproteinemia (HLP) is characterized by the presence of beta-migrating VLDL (beta-VLDL) and increased risk of cardiovascular disease. Assessment of plasma beta-VLDL is achieved by measuring the ratio of VLDL-cholesterol (VLDL-C) to total plasma triglycerides (TGs) or by detecting beta-VLDL in total VLDL. The objective of this study was to compare the clinical utility of the ratio of remnant-like particle-cholesterol (RLP-C) to total TGs with that of the current methods for diagnosing type III HLP.Detection of beta-VLDL by electrophoresis of VLDL was used to define type III HLP. Twenty-eight patients with type III HLP and 43 subjects lacking beta-VLDL were investigated. Fasting TG concentrations were2.26 mmol/L in all subjects. Subjects were separated into three groups: group 1, serum total cholesterol/=5.18 mmol/L (n = 11); group 2, total cholesterol5.18 mmol/L and TGs between 2.26 and 9.04 mmol/L (n = 51); and group 3, TGs9.04 mmol/L (n = 9).In group 2, a RLP-C-to-total TG molar ratio/=0.23 (/=0.10 when using mg/dL) and a VLDL-C-to-total TG molar ratio/=0.69 (/=0.30 when using mg/dL) correctly classified 94% and 90% of the subjects, respectively. The utility of the RLP-C-to-total TG ratio in diagnosing type III HLP decreased in patients in the other two groups.When used in an appropriate target population, the RLP-C-to-total TG ratio is a convenient and effective alternative to ultracentrifugal and electrophoretic methods for diagnosing type III HLP. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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