| Autor: |
Qian, Xie, Mareike M, Wiedmann, Aishan, Zhao, Ivelisse R, Pagan, Richard P, Novick, Hiroaki, Suga, Tom W, Muir |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Chem Commun (Camb) |
| ISSN: |
1364-548X |
| Popis: |
We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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