Cyclosporine versus tacrolimus maintenance therapy in renal transplant
| Autor: | Saad, Alghamdi, Zahid, Nabi, Edward, Skolnik, Lutfi, Alkorbi, Mamdouh, Albaqumi |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Graft Rejection Male Chi-Square Distribution Time Factors Graft Survival Saudi Arabia Blood Pressure Middle Aged Kidney Transplantation Survival Analysis Tacrolimus Survival Rate Young Adult Cholesterol Treatment Outcome Creatinine Cyclosporine Humans Female Biomarkers Immunosuppressive Agents Retrospective Studies |
| Zdroj: | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 9(3) |
| ISSN: | 2146-8427 |
| Popis: | Several studies have shown comparable results in long-term graft and patient survival, comparing a tacrolimus-based therapy to cyclosporine, while other studies have shown that a tacrolimus-based regimen had a better renal function with fewer episodes of acute rejection. Most of these studies were in a white population. We describe our experiences comparing tacrolimus versus cyclosporine maintenance therapy in a Saudi population.All patients from 2003 until 2008 in our transplant clinic were evaluated. A retrospective analysis was done comparing patient and graft survival, kidney function, and metabolic profile.There was no statistical difference in acute rejection rate between the cyclosporine group and the tacrolimus group (18.7% vs 20.9%; P = .756). Mean serum creatinine was not statistically different between the 2 groups. Patient and graft survival at 1 and 2 years also were similar. Although patient and graft survival were similar, the cyclosporine group had a higher level of cholesterol compared with the tacrolimus group (4.6 ± 1.03 mmol/L vs 4.1 ± 0.80 mmol/L; P = .010).There is no difference in 1- or 2-year patient and graft survival between patients maintained on cyclosporine compared with tacrolimus. However, patients on cyclosporine had a higher blood pressure and serum cholesterol level. |
| Databáze: | OpenAIRE |
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