[Kinetic mechano-chemical model of a muscle with a six-stage cross-bridge cycle]

Autor:	A K, Tsaturian
Rok vydání:	1991
Předmět:	Adenosine Diphosphate Kinetics Adenosine Triphosphate Hydrolysis Muscles Temperature Actomyosin Models Theoretical Muscle Contraction Phosphates
Zdroj:	Biofizika. 36(4)
ISSN:	0006-3029
Popis:	A kinetic scheme of the mechano-chemical cycle of the cross-bridges and a mathematical model based on this scheme are proposed. The main assumptions accepted in the scheme are: the step of the inorganic phosphate release precedes the force-generating step of a cross-bridge; the rate-limiting step of the ATP hydrolysis is isomerization of the actomyosin-ADP complex. It is shown that the model well describes the mechanical and biochemical transients initiated by the temperature jump and flash photolysis of the caged compounds in skinned muscle fibres.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::03e99923a44440737422f3f09e3c1715 https://pubmed.ncbi.nlm.nih.gov/1793752 Zobrazit plný text záznamu