Validation of FDG uptake in the arterial wall as an imaging biomarker of atherosclerotic plaques with 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT)
| Autor: | Monica, Bucci, Carina Mari, Aparici, Randy, Hawkins, Steve, Bacharach, Carole, Schrek, Suchun, Cheng, Elizabeth, Tong, Sandeep, Arora, Eugenio, Parati, Max, Wintermark |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Metabolic Clearance Rate Angiography Reproducibility of Results Arteries Middle Aged Atherosclerosis Models Biological Multimodal Imaging Sensitivity and Specificity Article Fluorodeoxyglucose F18 Positron-Emission Tomography Image Interpretation Computer-Assisted Humans Female Tissue Distribution Whole Body Imaging Radiopharmaceuticals Tomography X-Ray Computed Biomarkers |
| Zdroj: | Journal of neuroimaging : official journal of the American Society of Neuroimaging. 24(2) |
| ISSN: | 1552-6569 |
| Popis: | From the literature, the prevalence of fluorodeoxyglucose (FDG) uptake in large artery atherosclerotic plaques shows great heterogeneity. We retrospectively reviewed 100 consecutive patients who underwent FDG-positron emission tomography-computed tomography (PET/CT) imaging of their whole body, to evaluate FDG uptake in the arterial wall.We retrospectively evaluated 100 whole-body PET-CT scans. The PET images coregistered with CT were reviewed for abnormal 18F-FDG uptake. The mean standard uptake value (SUV) was measured in regions of interest (ROIs). The prevalence of PET+ plaques was determined based on the qualitative PET review, used as the gold standard in a receiver-operating characteristic (ROC) curve analysis to determine an optimal threshold for the quantitative PET analysis.The qualitative, visual assessment demonstrated FDG uptake in the arterial walls of 26 patients. A total of 85 slices exhibited FDG uptake within the arterial wall of 37 artery locations. 11, 17, and 2 patients exhibited FDG uptake within the wall of carotid arteries, of the aorta, and of the iliac arteries, respectively. Only 4 of the 26 patients had positive FDG uptake in more than one artery location. In terms of quantitative analysis, a threshold of 2.8 SUV was associated with a negative predictive value of 99.4% and a positive predictive value of 100% to predict qualitative PET+ plaques. A threshold of 1.8 SUV was associated with a negative predictive value of 100% and a positive predictive value of 99.4%. Area under the ROC curve was .839.The prevalence of PET uptake in arterial walls in a consecutive population of asymptomatic patients is low and usually confined to one type of artery, and its clinical relevance in terms of vulnerability to ischemic events remains to be determined. |
| Databáze: | OpenAIRE |
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