| Autor: |
Chun Xiang, Tang, Hong Yan, Qiao, Xiao Lei, Zhang, Meng, Di Jiang, U Joseph, Schoepf, Piotr Nikodem, Rudziński, Dominic P, Giovagnoli, Meng Jie, Lu, Jian Hua, Li, Yi Ning, Wang, Jia Yin, Zhang, Yang, Hou, Min Wen, Zheng, Bo, Zhang, Dai Min, Zhang, Xiu Hua, Hu, Lei, Xu, Hui, Liu, Guang Ming, Lu, Long Jiang, Zhang |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
European radiology. 32(8) |
| ISSN: |
1432-1084 |
| Popis: |
To propose a novel functional Coronary Artery Disease-Reporting and Data System (CAD-RADS) category system integrated with coronary CT angiography (CCTA)-derived fractional flow reserve (FFRFirstly, we proposed a novel functional CAD-RADS and evaluated the performance of functional CAD-RADS for guiding treatment strategies with actual clinical treatment as a reference standard in a retrospective multicenter cohort with CCTA and invasive FFR performed in all patients (n = 466). Net reclassification improvement (NRI) of functional CAD-RADS over anatomical CAD-RADS was calculated. Secondly, the prognostic value of functional CAD-RADS in a prospective two-arm cohort (566 [FFRFunctional CAD-RADS demonstrated superior value over anatomical CAD-RADS (AUC: 0.828 vs. 0.681, p0.001) and comparable performance to FFR (AUC: 0.828 vs. 0.848, p = 0.253) in guiding therapeutic decisions. Functional CAD-RADS resulted in the revision of management plan as determined by anatomical CAD-RADS in 30.0% of patients (n = 140) (NRI = 0.369, p0.001). Functional CAD-RADS was an independent predictor for 1-year outcomes with indexes of concordance of 0.795 and the corresponding value was 0.751 in anatomical CAD-RADS.The novel functional CAD-RADS gained incremental value in guiding therapeutic decision-making compared with anatomical CAD-RADS and comparable power in 1-year prognosis with anatomical CAD-RADS in a real-world scenario.• The novel functional CAD-RADS category system with FFR |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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