Hepatocytic Apoptosis and Immune Dysfunction in Decompensation of Alcoholic Liver Cirrhosis with Different Grades of Acute-on-Chronic Liver Failure

Autor:	A S, Rodina, M E, Shubina, I V, Kurbatova, L V, Topchieva, O P, Dudanova
Rok vydání:	2021
Předmět:	Liver Cirrhosis Liver Cirrhosis Alcoholic Acute-On-Chronic Liver Failure Humans Apoptosis
Zdroj:	Bulletin of experimental biology and medicine. 172(4)
ISSN:	1573-8221
Popis:	Acute-on-chronic liver failure (ACLF) of varying grades was assessed in 110 patients with alcoholic liver cirrhosis using the on-line CLIF-C ACLF Calculator ( www.efclif.com/scientific-activity/score-calculators/clif-c-aclf ); fragments of cytokeratin-18, TNFα, IL-1β, IL-4, IL-6, and IL-8 were also assayed. As ACLF progressed from grade 0 to grade 3, the levels of cytokeratin-18 fragments, IL-6, and IL-8 significantly increased, while IL-4 decreased. TNFα peaked in ACLF grade 1, but decreased in grades 2 and 3. IL-1β did not depend on the ACLF grade. Thus, hepatic damage and immune dysfunction are implicated in the progression of ACLF.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::03bf7b25c1f8365b7314b112db2ac725 https://pubmed.ncbi.nlm.nih.gov/35175469 Zobrazit plný text záznamu Full text from SpringerLink