| Autor: |
Tae, Yamamoto, Marcelo M, Nascimento, Shirley Y, Hayashi, Abdul Rashid, Qureshi, Jacek, Waniewski, Lars Åke, Brodin, Björn, Anderstam, Britta, Lind, Miguel C, Riella, Astrid, Seeberger, Bengt, Lindholm |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Hemodialysis international. International Symposium on Home Hemodialysis. 17(1) |
| ISSN: |
1542-4758 |
| Popis: |
The hemodialysis (HD) procedure induces an inflammatory response potentially contributing to cardiovascular disease. Here we investigated the acute impact of HD on circulating biomarkers. Circulating biomarkers (small solutes, middle molecular-sized peptides, and proteins) related to inflammation, oxidative stress, and vascular calcification (VC) were measured before and after a single session of HD in 45 clinically stable patients. Concentrations were corrected for ultrafiltration-induced hemoconcentration. Among vascular calcification-related biomarkers, osteoprotegerin and fetuin-A remained unchanged while fibroblast growth factor-23 (FGF23) decreased by -19%. Changes of FGF23 and changes of phosphate correlated (ρ = 0.61, P0.001). While C-reactive protein did not change, interleukin-6 (IL-6) increased by 14% and pentraxin 3 (PTX3) increased by 45%. IL-6 and PTX3 appear to be valid biomarkers of the intradialytic inflammatory response. VC-related markers were in general not affected by the single HD session; however, the observed correlation between acute changes of FGF-23 and phosphate during HD warrants further studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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