| Autor: |
A L, Evdonin, D B, Tvorogov, N V, Tsupkina, N N, Nikol'skiĭ, N D, Medvedeva |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Tsitologiia. 40(7) |
| ISSN: |
0041-3771 |
| Popis: |
It is known that the growth factor activates appropriate membrane receptors which become starting points of cascades of protein-protein interactions leading to cellular response. Recent data suggest that different signalling pathways may cross-talk during the cellular response. Here we show that phosphoinositide-specific phospholipase C gamma 1, one of the key elements in phosphoinositide pathway of signal transduction, is physically associated with members of the STAT pathway. The precipitation of phospholipase C gamma 1, using polyclonal antibody in A-431 cells, leads to co-immunoprecipitation of STAT1 alpha and STAT1 beta, as well as STAT3. The formation of such complexes was observed in both unstimulated and EGF stimulated cells. The participation of SH3-domains in the formation of such complexes is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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