| Autor: |
E I, Kalenikova, O F, Dmitrieva, N V, Korobov, S V, Zhukovskiĭ, V A, Tishchenko |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Voprosy meditsinskoi khimii. 34(1) |
| ISSN: |
0042-8809 |
| Popis: |
Pharmacokinetics of a new anti-ulcer drug, synthetic opioid hexapeptide dalargin (Tyr-D-Ala-Gly-Phe-Leu-Arg), which is an analogue of Leu-enkephalin, was studied in rats. Distribution and metabolism of 3H-Tyr-dalargin were examined after intravenous administration at a dose of 150 mg/kg. Main Tyr-containing metabolites of dalargin were detected and dynamics of their concentrations was evaluated in blood within 1 hr after administration. Kinetic curve of dalargin was described as three-exponential function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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