| Autor: |
S, Iacobelli, L, Irtelli, R, Sacco, M, Martino, E, Mascitelli, L, Basilico, M, Scognamiglio, C, Natoli, O, Fusco, N, Tinari, V, Beltrami |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Anticancer research. 18(3B) |
| ISSN: |
0250-7005 |
| Popis: |
The survival rate for surgically resected stage III N2 non-small cell lung cancer (NSCLC) patients is less than 10%.A phase II study of cisplatin, epirubicin, and VP-16 (PEV) was undertaken in an attempt to improve the curative potential of surgery. Forty-one patients with stage III N2 NSCLC received 3 cycles of pEV. Patients with either complete response (CR) or partial response (PR) underwent surgery and 3 additional courses of PEV.The response rate in the whole patient population was 58%. Eighteen patients were resected; twelve resections were complete and 6 were incomplete. Toxicity was mild and consisted mainly of myelosuppression. Twenty-six patients have died, and the median survival of all 41 patients was 18.1 months, with a 3-year survival of 23%. The median survival for those patients who were resected was 27 months with a 3-year survival of 42%.PEV is an effective low toxic drug combination for limited NSCLC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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