The sentinel node in cervical cancer patients: role of tumor size and invasion of lymphatic vascular space

Autor: Petros, Zarganis, Agatha, Kondi-Pafiti, Petroula, Arapantoni-Dadioti, Erasmia, Trivizaki, Konstantinos, Velentzas, George, Vorgias, Stelios, Fotiou
Rok vydání: 2009
Předmět:
Zdroj: In vivo (Athens, Greece). 23(3)
ISSN: 0258-851X
Popis: The sentinel lymph node (SLN) technique aims at predicting the absence of regional nodal metastasis and seems promising in the management of cervical cancer patients.Forty patients undergoing surgery for early cervical cancer were submitted to the SLN procedure, using Blue Patente alone in 3, radiocolloid injection alone in 4 and both methods in 33 (82.5%). All patients underwent radical hysterectomy and pelvic lymphadenectomy.The detection rate was as follows: overall 85%, blue dye alone 66%, radiocolloid alone 75%, dual method 87%. Detection was successful in 34 patients, with one false-negative result. No micrometastases were demonstrated during ultrastaging of the sentinels. The detection rate was higher in tumors2 cm (94.1%) than in larger tumors (78.2%, p0.09). Significant negative correlation between lymphatic vascular space invasion (LVSI) and detection rate was found (p0.001).SLN detection is feasible in early cervical cancer but presence of LVSI and a tumor size2 cm negatively affect the detection rate and may increase the incidence of false negatives.
Databáze: OpenAIRE