Distinct contributions of the fornix and inferior longitudinal fasciculus to episodic and semantic autobiographical memory
| Autor: | Carl J, Hodgetts, Mark, Postans, Naomi, Warne, Alice, Varnava, Andrew D, Lawrence, Kim S, Graham |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Research Report Brain Mapping Adolescent Memory Episodic Structural connectivity White matter tractography Fornix Brain Individuality Brain Organ Size Neuropsychological Tests White Matter Hippocampus Young Adult Diffusion Magnetic Resonance Imaging Individual differences Image Processing Computer-Assisted Humans Female Mental time travel Gray Matter Nerve Net Temporal lobe |
| Zdroj: | Cortex; a Journal Devoted to the Study of the Nervous System and Behavior |
| ISSN: | 1973-8102 |
| Popis: | Autobiographical memory (AM) is multifaceted, incorporating the vivid retrieval of contextual detail (episodic AM), together with semantic knowledge that infuses meaning and coherence into past events (semantic AM). While neuropsychological evidence highlights a role for the hippocampus and anterior temporal lobe (ATL) in episodic and semantic AM, respectively, it is unclear whether these constitute dissociable large-scale AM networks. We used high angular resolution diffusion-weighted imaging and constrained spherical deconvolution-based tractography to assess white matter microstructure in 27 healthy young adult participants who were asked to recall past experiences using word cues. Inter-individual variation in the microstructure of the fornix (the main hippocampal input/output pathway) related to the amount of episodic, but not semantic, detail in AMs – independent of memory age. Conversely, microstructure of the inferior longitudinal fasciculus, linking occipitotemporal regions with ATL, correlated with semantic, but not episodic, AMs. Further, these significant correlations remained when controlling for hippocampal and ATL grey matter volume, respectively. This striking correlational double dissociation supports the view that distinct, large-scale distributed brain circuits underpin context and concepts in AM. |
| Databáze: | OpenAIRE |
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