Angiostatic proteins and peptides
| Autor: | J C, Bouma-ter Steege, K H, Mayo, A W, Griffioen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Collagen Type IV
Vascular Endothelial Growth Factor A Integrins Lymphokines Vascular Endothelial Growth Factors Proteins Angiogenesis Inhibitors Antineoplastic Agents Plasminogen Endothelial Growth Factors Matrix Metalloproteinase Inhibitors Autoantigens PHEX Phosphate Regulating Neutral Endopeptidase Peptide Fragments Endostatins Fibroblast Growth Factors Thrombospondin 1 Cell Migration Inhibition Cell Adhesion Animals Humans Collagen Endothelium Vascular Angiostatins Oligopeptides |
| Zdroj: | Critical reviews in eukaryotic gene expression. 11(4) |
| ISSN: | 1045-4403 |
| Popis: | Angiogenesis, or the formation of new vasculature out of preexisting capillaries, is a sequence of events that is essential in the normal physiological processes of tissue growth and in a broad spectrum of pathologies. The diseases in which angiogenesis plays a key role are divided into diseases that are characterized by hypoxia/ ischemia and diseases that are dependent on neovascularization. The formerpathologies may benefit from therapeutic angiogenesis stimulation. This review concentrates on the different strategies to inhibit angiogenesis in diseases that are characterized by excessive angiogenesis, for example, cancer, arthritis, diabetic retinopathy, and inflammatory diseases. These diseases are dependent on the development of newvasculature, and hence, a large variety of different strategies to inhibit angiogenesis are underwayin laboratories throughout the world. At present, over250 angiogenesis inhibitors are described, and approximately half of them display activity in in vivo models. A large percentage of these molecules are natural, nonnatural, or synthetic so-called small molecules. Others are of protein origin, either endogenous or exogenous by nature. The authors highlight the current knowledge on the development of angiostatic proteins and peptides and their potential in the treatment of disease. |
| Databáze: | OpenAIRE |
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