Effects of Antibodies to Glutamate on Cerebral Expression of the Tnfrsf1A Gene under Conditions of Spatial Amnesia Induced by Proinflammatory Protein S100A9 Fibrils in Aging Mice

Autor:	M A, Gruden, T V, Davydova, A M, Ratmirov, R D E, Sewell
Rok vydání:	2021
Předmět:	Inflammation Male Aging Tumor Necrosis Factor-alpha Glutamic Acid Prefrontal Cortex Hippocampus Antibodies Mice Inbred C57BL Mice Receptors Tumor Necrosis Factor Type I Cerebellum Animals Calgranulin B Amnesia Spatial Memory Spatial Navigation
Zdroj:	Bulletin of experimental biology and medicine. 172(1)
ISSN:	1573-8221
Popis:	Proinflammatory S100A9 protein is a promoter of inflammation-linked neurodegeneration and the Tnfrsf1A gene encodes the TNF receptor 1A that binds TNFα to function as a regulator of inflammation. We studied the effects of chronic intranasal administration of in vitro prepared S100A9 fibrils alone or in combination with anti-glutamate antibodies on the expression of the Tnfrsf1A gene in the hippocampus, prefrontal cortex, and cerebellum of aging C57BL/6 mice under conditions of impaired spatial memory. A differential cerebral pattern of Tnfrsf1A gene activity and its modification by S100A9 fibrillar structures were observed: inhibition of Tnfrsf1A gene expression in the hippocampus and cerebellum and its activation in the prefrontal cortex. Anti-glutamate antibodies normalized the expression of the Tnfrsf1A gene in the prefrontal cortex by affecting the TNF signaling pathway and preventing the development of inflammation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::02facfbf58ed0d9b6ed36a401ed7d2e8 https://pubmed.ncbi.nlm.nih.gov/34796426 Zobrazit plný text záznamu Full text from SpringerLink