| Autor: |
Yi-Chih, Hung, Wen-Shin, Chang, An-Kuo, Chou, Jen-Sheng, Pei, Mei-Due, Yang, Horng-Ren, Yang, Ta-Ming, Yang, Yun-Chi, Wang, Yu-Chen, Hsiau, Chou-Pin, Chen, Chou-Chen, Chen, Chien-Chih, Yu, Chia-Wen, Tsai, DA-Tian, Bau |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Anticancer research. 40(3) |
| ISSN: |
1791-7530 |
| Popis: |
To investigate the association between adiponectin (ADIPOQ) genotypes and colorectal cancer (CRC) risk among Taiwanese.Polymerase chain reaction-restriction fragment length polymorphism was adopted to identify ADIPOQ rs266729, rs2241766 and rs1501299 genotypes among 362 CRC patients and 362 healthy controls.ADIPOQ rs266729 GG genotype (p=0.0075) and G allele (p=0.0061) are associated with a significantly increased CRC risk. There is no differential distribution of rs2241766 and rs1501299 genotypes. As for the gene-lifestyle interaction, there are obvious joint effects of rs266729 genotype on the CRC risk among non-smoker, non-alcohol drinker, while not on smoker or non-drinker subgroups. No significant correlation was observed between rs266729 genotypic distributions and age, gender, tumor size, location or metastasis status. Interestingly, a correlation of rs266729 genotype and larger BMI on CRC risk was found.G allele at ADIPOQ rs266729 may serve as a determiner for CRC risk, especially for those with BMI ≥24. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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