Myricetin-induced oxidative stress suppresses murine T lymphocyte activation

Autor:	Javad, Ghassemi-Rad, Mahdis, Maleki, Allison F, Knickle, David W, Hoskin
Rok vydání:	2017
Předmět:	Flavonoids T-Lymphocytes Dendritic Cells Hydrogen Peroxide Lymphocyte Activation Acetylcysteine Mice Inbred C57BL Interferon-gamma Mice Oxidative Stress Animals Interleukin-2 Female Reactive Oxygen Species Cells Cultured Cell Proliferation
Zdroj:	Cell biology international. 42(8)
ISSN:	1095-8355
Popis:	A number of polyphenolic compounds present in fruits and vegetables have the capacity to modulate immune responses; however, the impact of the common plant-derived flavonoid myricetin on T lymphocyte function has not been investigated. We show that myricetin inhibited mouse T lymphocyte activation by bead-immobilized anti-CD3 and anti-CD28 monoclonal antibodies, as indicated by a dose-dependent reduction in cell proliferation and decreased synthesis of interferon-γ, interleukin (IL)-2, IL-4, and IL-17 associated with different T helper cell subsets. This effect was attributed to myricetin-induced reactive oxygen species (ROS) since myricetin caused hydrogen peroxide (H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::02e1d71d5342878ce93c05c9c47f35f2 https://pubmed.ncbi.nlm.nih.gov/29745443 Zobrazit plný text záznamu Plný text