Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients
| Autor: | Scalioni, Letícia de Paula, dos Santos, Betânia Rodrigues, Spritzer, Poli Mara, Villela-Nogueira, Cristiane Alves, Laura Lewis-Ximenez, Lia, Pollo-Flores, Priscila, Bordalo Cathalá Esberard, Eliane, Brandão-Mello, Carlos Eduardo, Lampe, Elisabeth, Villar, Livia Melo |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Potential relationship of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (DBP) have been suggested in the pathophysiology of hepatitis C virus (HCV) infection. The aim of this observational study is to determine vitamin D levels, and VDR and DBP genetic polymorphism according demographic and laboratory data in chronic HCV patients (CHC). A total of 148 CHC patients gave serum samples for testing 25-hydroxyvitamin D (25 (OH)D) level by immunochemiluminometric assay (A, rs731236 A>G (TaqI), rs1544410 C>T (BsmI), rs10735810 T>C (FokI) and carrier globulin/binding protein (GC)-rs4588 and rs7041 and the haplotype bAt [CCA]. Hepatic fibrosis was assessed using Fib-4 and Forns index. Eighty-two (54.40%) patients demonstrated deficiency of vitamin D and this was associated to AST (P = .019 [CI: 1.003–1.034]), total cholesterol (P = .038 [CI: 1.004–1.164]), fibrosis grade (P |
| Databáze: | OpenAIRE |
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